Disease and Illnesses of dogs – urinary incontinence – Propalin

What is Propalin for Dogs?

Propalin is a drug used to control urinary incontinence which is caused by urethral sphincter mechanism incompetence (SMI) in neutered bitches. Propalin contains the active ingredient phenylpropanolamine in the form of phenylpropanolamine hydrochloride. Propalin is manufactured by Vetoquinol UK Ltd and is a clear, colourless liquid which comes in bottles of 30ml or 100ml. The dose of Propalin will be calculated by your vet and is given three times a day by mouth.

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What is Propalin used for?

Propalin is used to treat urinary incontinence in neutered bitches. Propalin is used in cases where urethral sphincter mechanism incompetence (SMI) is the underlying cause of the incontinence. Propalin contains phenylpropanolamine which stimulates the nerves that control the urethra and cause it to hold closed more firmly, therefore preventing the leaking of urine. Propalin is only effective in neutered bitches and is not useful in cases of inappropriate urination with underlying behavioural causes. Treatment with Propalin is usually lifelong.

Propalin Tips

  • Propalin should only be given to neutered bitches
  • Propalin should be used as directed by your Vet
  • Propalin is given three times a day
  • Propalin is a clear, colourless liquid, given by mouth
  • If you suspect side effects from Propalin then contact your Vet
  • If your pet has received an overdose of Propalin, contact your Vet for advice
  • The dose of Propalin is based on weight so weigh your pet regularly
  • Propalin is available as bottles of either 30ml or 100ml
  • Store Propalin under 250C but not refrigerated
  • Discard open Propalin after 3 months

 Potential Side Effects of Propalin Syrup for Dogs

  • Propalin can cause inappetance, loose stools or diarrhoea
  • Propalin may cause restlessness and in severe cases collapse
  • Propalin may increase blood pressure and heart rate and can cause arrhythmias
  • These side effects can resolve if treatment is stopped
  • Do not use Propalin in pregnant or lactating animals
  • If you suspect side effects then call your vet for advice
  • An overdose of Propalin can cause severe cases of the above side effects
  • If you suspect an overdose then call your vet as soon as possible
  • Wash hands if Propalin comes into contact with the skin
  • Propalin should be used with care in animals with Diabetes, Cushings, Liver and Kidney disease

 Dosage and Administration

  • Propalin is a clear, colourless syrup
  • Propalin is given orally, three times a day
  • Propalin comes with a 1.5ml graduated syringe for ease of dosing
  • The dose of Propalin is 0.8mg phenylpropanolamine per kg bodyweight
  • This equates to 0.1ml Propalin syrup per 5kg bodyweight
  • Do not change the dose rate without speaking to your vet first
  • Propalin is better absorbed on an empty stomach
  • Propalin is available in 30ml and 100ml bottles
  • The dose is based on your pet’s weight so weigh your pet regularly

 Further Information about Propalin

Propalin contains the active ingredient phenylpropanolamine which is used in the treatment of neutered bitched who are suffering with urinary incontinence. Propalin is used in cases where urethral sphincter mechanism incompetence is the underlying cause of the incontinence. Urethral sphincter mechanism incompetence occurs in neutered bitches and it is in these animals that Propalin works. Propalin should not be used in entire bitches. Propalin is available as a 40mg/ml syrup in bottles of 30ml or 100ml and is given orally three times a day.

Phenylpropanolamine is a “sympathomimetic” drug which stimulates alpha adrenergic receptors in nerves. This means that Propalin mimics the sympathetic nervous system, responsible for “flight or fight” as this also causes urine to be retained. Propalin stimulates the alpha adrenergic receptors in the nerves that control the urethra and cause an increase in the pressure that keeps the urethra closed which acts to retain the urine and stop it leaking from the animal.

Propalin can have some side effects, especially at high doses and these are related to over stimulation of the sympathetic nervous system. These include diarrhoea, increased heart rate and blood pressure, restlessness, dizziness and in severe cases, collapse. These are usually reversible when treatment with Propalin is stopped. If you suspect any potential side effects then contact your vet.

Further Information on dosage and administration of Propalin

The dose rate for Propalin is 0.8mg of the active ingredient phenylpropanolamine per kg bodyweight. The concentration of Propalin is 40mg phenylpropanolamine per ml syrup so this equates to 0.1ml Propalin syrup per 5kg of bodyweight. Propalin syrup comes in bottles of either 30ml or 100ml and there is a specific graduated dosing syringe for ease of accurate dosing. The dose of Propalin is given three times a day by mouth. Propalin is absorbed better and is therefore more effective if given to fasted dogs, on an empty stomach.

Propalin should not be given to intact i.e. Non neutered bitches, especially if they are pregnant or lactating. Propalin should be used with care in animals with Diabetes, Cushings, Kidney or Liver disease or any other underlying metabolic disease. In animals under 1 year of age, there can be an anatomical reason for the urinary incontinence and it should be attempted to rule this out before starting treatment with Propalin.

If you suspect any adverse effects from Propalin then contact your vet as soon as possible. Do not alter the dose of Propalin without first consulting your vet. Treatment with Propalin is usually life-long.

Other products commonly used for incontinence include Incurin and Urilin.

Frequently Asked Questions

Q. What does Propalin do?                                                                                                                                       

A. Propalin is used to treat urinary incontinence. It does this by stimulating nerves and increasing the pressure that holds the urethra closed.

Q. How is Propalin given?                                                                                                                                            

A. Propalin is a clear syrup that is given by mouth, ideally on an empty stomach.

Q. How often is Propalin given?

A. Propalin is given three times a day as it does not last for long in the body.

Q. How long will my pet need to be on Propalin?

A. Once started, treatment with Propalin is usually lifelong.

Q. Will I need to return to my vets for check ups? 

A. Yes. Whilst on Propalin your pet will need to be checked every 6 months minimum, more often if the condition is not stable.

Q. My dog has been stable but has started leaking again, should I increase the dose of Propalin?

A. No, there can be other factors that complicate the incontinence. Do not alter the dose without checking with your vet.

Q. Can Propalin have side effects?

A. Yes, Propalin can have side effects such as going off the food, diarrhoea and restlessness.

Q. I think my pet is suffering adverse effects from Propalin, should I stop the medication?                       

A. Some side effects can resolve when medication is stopped but you must check with the vet first.

Q. My dog has just chewed and eaten a whole bottle of Propalin, what should I do?                               

A. You should contact your vet as soon as possible for advice if you suspect an overdose of Propalin.

 


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