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Incurin

Incurin

What is Incurin?

Incurin is a drug that is used to control urinary incontinence in dogs, specifically spayed bitches. Incurin is manufactured by Intervet Schering – Plough and contains the active ingredient Estriol, a type of oestrogen. Incurin comes in packs of 30 small, scored tablets. The dose rate is simple, starting at 1 tablet per dog per day and can be reduced if treatment is successful.   

What is Incurin used for?

Incurin is used to control urinary incontinence in spayed bitches. This is a hormonal problem resulting in the urethral sphincter muscle being weaker than usual meaning that urine can leak out unconsciously. This is called urethral sphincter mechanism incompetence (SMI).

Incurin contains the active ingredient Estriol which is a type of Oestrogen. Oestrogen is a hormone which causes the muscular urethral sphincter to tighten and as a result it can more easily control urination, stopping the leaking.

Incurin has only been shown to be effective in spayed bitches, it has not been shown to be effective in intact bitches or in male dogs.

Incurin Tips

·      Only give Incurin as advised to do so by your vet.

·      Do not alter the dose rate without checking with your vet first.

·      Incurin is only given once daily.

·      If you suspect any side effects from Incurin then contact your vet

·      If you accidentally overdose your pet then call your vet for advice.

·      Incurin does not always need to be given every day

·      Animals taking Incurin should be re checked every 6 months.

·      Incurin is available as small, white, scored tablets.

·      Do not store above 30oC

Side Effects

·      Incurin can have side effects at high doses.

·      Side effects are most likely to occur if animals are receiving >2 tablets per day.

·      Side effects from Incurin are related to the oestrogen increasing female traits.

·      Incurin can cause a swollen vulva and increased attractiveness to males.

·      Incurin can cause an increase in size of mammary tissue.

·      Side effects are reversible if the dose of Incurin is lowered.

·      Incurin should not be used in pregnant animals.

·      Incurin should not be used in intact bitches.

·      Incurin should not be used in animals less than 1 year old.

·      In very rare cases vaginal bleeding and hair loss can be seen.

Dosage and Administration

·      Each Incurin tablet contains 1mg active ingredient, Estriol.

·      The initial dose rate of Incurin is 1 tablet per dog per day.

·      Incurin tablets are given orally.

·      If there is a good response to treatment then the dose can be lowered

·      If your pet doesn’t respond to Incurin then the dose can be increased.

·      Incurin tablets are small, round and white.

·      Incurin tablets are scored so they can be broken easily.

·      The dose of Incurin is tapered to the lowest effective dose.

·      Incurin should not be used in animals that are drinking or urinating excessively due to another disease process.

Further Information about Incurin

Incurin is a drug which contains the active ingredient Estriol. Estriol is an oestrogen which is a hormone produced by entire bitches. When bitches undergo an ovariohysterectomy or are spayed, the lack of oestrogen can cause the urethral sphincter to weaken. This is called Urethral sphincter mechanism incompetence (SMI). The result of this is that bitches leak urine instead of being able contain the urine within the bladder until an appropriate time.

The Estriol in Incurin causes the muscle of the urethral sphincter to tighten to give better control over urination and prevent the leaking of urine. There is 1mg of Estriol in each Incurin tablet and these tablets are given daily.

Incurin is a POM-V, which means it is a drug that can only be obtained by the vet that is treating your pet or via a prescription from them. Incurin is manufactured by Intervet  Schering-Plough and is available in blister pack of 30 small, white, scored tablets. If you suspect either an overdose or any side effects from Incurin then contact your vet for advice.

Further Information about Dosage and Administration of Incurin

The dose rate of Incurin is very simple and is not related to the bodyweight of the dog. The initial dose rate of Incurin is 1 tablet per dog per day. If the response to this dose is good then you can try and taper the dose to half a tablet daily, conversely if the response to this dose is not good and the incontinence continues then you can increase the dose to 2 tablets per dog per day. Ideally the dose of Incurin is tapered to the lowest effective dose. You should however not alter the dose without first consulting your vet.

Each Incurin tablet contains 1mg of the active ingredient Estriol. The Incurin tablets themselves are small, round white tablets which come in blister packs of 30 tablets. The Incurin tablets are also scored to make it easier to split them for dogs that need dosages involving half a tablet. Incurin tablets are given orally once daily.

Incurin tablets are generally very safe if administered as advised to do so by your vet but can have side effects when given at the higher end of the dose range. These side effects are mainly related to feminisation which is an effect of the oestrogen in the Incurin. Side effects of Incurin can include increased size of mammary tissue, swelling of the vulva and increased attractiveness to males. In rare cases, bleeding from the vulva can occur and occasionally hair loss. These side effects are reversible when the dose of Incurin is reduced.

If you see any potential side effects from Incurin or if you think your dog has accidentally received an overdose of Incurin then call your vet for advice.

Frequently asked Questions

Q. What does Incurin do?                                                                                                                                              A. Incurin helps to control urinary incontinence in neutered bitches.

Q. How does Incurin work?                                                                                                                                       A. Incurin contains the hormone oestrogen which causes the urethral sphincter to tighten and controls urination.

Q. How are Incurin tablet given?                                                                                                                         A. Incurin tablets are given orally, once daily.

Q. Can Incurin tablets be split?                                                                                                                                  A. Yes, Incurin tablets are scored to make then easy to split for doses needing half a tablet?

Q. How long will my pet need to take Incurin?                                                                                                  A. Medication with Incurin is usually lifelong but the dose will be reduced to the lowest effective dose.

Q. How often will I need to go back to the vets for rechecks?                                                                       A. Once your pet is stable then it is advised to recheck with the vet every 6 months. Rechecks may be more frequent than that initially.

Q. My dog has started leaking urine again, should I increase the dose?                                                            A. No. You shouldn’t change the dose without checking with the vet. You should call your vet for advice.

Q. My pet has accidentally eaten the entire box of Incurin, what should I do?                                                                               A. If you suspect an overdose of Incurin then you should contact your vet as soon as possible for advice.

 

Q. Can Incurin have any side effects?                                                                                                                        A. Incurin can have side effects, usually when it is being given at the higher end of the dose range. These can include increase in size of mammary tissue, a swollen vulva and increased attractiveness to males.

Q. Should I stop the medication if I see side effects?
A. The first thing you should do is contact the vet but most of the side effects are reversible when the dose of medication is lowered.